Faculty of medicine researchers were awarded more than $36 million in funding through the Canadian Institutes of Health Research (CIHR) Project Grants: Spring 2022 competition.
In total, this competition approved 405 research grants, plus two bridge grants, for a total investment of approximately $325 million. In addition, 61 priority announcement grants were funded for a total amount of $10,779,207 and 16 supplemental prizes were awarded for a total of $1,060,000.
Faculty of medicine principal investigators and their projects:
Project grants
Purang Abolmaesumi, School of Biomedical Engineering and Michael Y. Tsang and Teresa S. Tsang, Department of Cardiology
Automatic Assessment of Aortic Stenosis with Point of Care Ultrasound
Francois Benard, Department of Radiology
Development of second-generation radiopharmaceuticals targeting the C-X-C chemokine receptor 4 for imaging and therapy of hematological cancers
*Conditionally funded at time of posting
Inanc Birol, Department of Medical Genetics
Assembly and annotation of genomes, transcriptomes, and metagenomes
Jade Boyd, Department of Medicine
An intersectional investigation of women’s experiences of overlapping overdose and COVID-19 public health crises
Lara Boyd, Department of Physical Therapy
Gamifying neuro rehabilitation: Can we predict who will benefit?
Christopher Carlsten, School of Population and Public Health
Traffic-Related Air Pollution, Inhaled Corticosteroids and Host Defence Response in COPD
Mark S. Cembrowski, Department of Cellular and Physiological Sciences
A specialized neural circuit representing novelty on behavioural timescales
Ann Marie Craig, Department of Psychiatry
Targeting synaptic organizers in neuropsychiatric disorders
Pieter Cullis, Department of Biochemistry and Molecular Biology
Development of LNP/mRNA systems for direct transfection and generation of functional Chimeric Antigen Receptor (CAR) T-cells in-vivo for treatment of blood and other cancer cell types
*Conditionally funded at time of posting
Laura E. Evgin, Department of Medical Genetics
Leveraging TCR reactivity to improve CAR T therapy
Daniel Goldowitz, Department of Medical Genetics and Paul Pavlidis, Department of Psychiatry
Pax6 regulation of glutamatergic lineages in cerebellar development
David J. Granville, Department of Pathology and Laboratory Medicine
Novel mechanisms and therapeutic approach for aging-related pruritus
Ethan J. Greenblatt, Department of Biochemistry and Molecular Biology
Determining the role of FMRP complexes in autism-relevant gene expression
Pamela A. Hoodless, Department of Medical Genetics and School of Biomedical Engineering
Transcriptional Drivers of the Hepatic Lineage
*Conditionally funded at time of posting
Aly Karsan, Department of Pathology and Laboratory Medicine
Clonal interactions in myeloid malignancy
Aly Karsan, Department of Pathology and Laboratory Medicine
Role of SASH1 in generation of hematopoietic stem cells
Paul W. Kershaw, School of Population and Public Health
Applying Research about the Social/Medical Spending Ratio to Federal and Provincial Budget Allocations Between Ministries
Wan L. Lam, Department of Pathology and Laboratory Medicine
Targeting lung microbiome for developing early detection and intervention strategies for lung cancer
*Conditionally funded at time of posting
Blair R. Leavitt, Department of Medical Genetics
Lipid Nanoparticle-Mediated Delivery of CRISPR/Cas9 Gene Editing for Neurological Disorders.
Peter C. Leung and Alexander G. Beristain, Department of Obstetrics and Gynaecology
Role of BMP2 signaling at the maternal-fetal interface
*Conditionally funded at time of posting
Kuo-Shyan Lin, Department of Radiology
Next-generation GRPR-targeting radiopharmaceuticals with improved in vivo stability and minimized pancreas uptake
Sarka Lisonkova, Department of Obstetrics and Gynaecology
Health and neurodevelopmental trajectories of children and adolescents born at preterm and term gestation
Hongshen Ma, School of Biomedical Engineering
Behaviour-based cell separation to interrogate host cell heterogeneity in CAR-T cell therapies
Amee R. Manges, School of Population and Public Health, and Amin R. Javer, Department of Surgery
SinoNasal Microbiota Transfer (SNMT) to treat chronic rhinosinusitis: A randomized, double-blind, placebo-controlled trial
Deborah M. Money, Department of Obstetrics and Gynaecology
A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living with HIV
Ivan R. Nabi, Department of Cellular and Physiological Sciences
Role of MERCs and Mitophagy in Cancer Progression
William J. Panenka, Department of Psychiatry, Thalia S. Field, Department of Medicine and Cheryl L. Wellington, Department of Pathology and Laboratory Medicine
Traumatic brain injury and cerebral small vessel disease in a vulnerably housed cohort, a prelude to early neurodegeneration and dementia
Jacqueline A. Quandt, Department of Pathology and Laboratory Medicine
Targeting inflammatory and neurodegenerative pathways relevant to progression in the NR1H3 (LXRA) R415Q model of primary progressive multiple sclerosis
Alexander Rauscher, Department of Pediatrics
Quantitative Susceptibility Mapping from Clinical Phase Data
Elizabeth J. Rideout, Department of Cellular and Physiological Sciences
Understanding sex differences in the neuronal control of whole-body fat storage and breakdown
Amy L. Salmon, School of Population and Public Health
Family Matters: Engaging Loved Ones to Prevent Overdose Deaths in Semi-Urban and Rural Communities
Julia Schmidt, Department of Occupational Science and Occupational Therapy
Peers Actively Involved in Rehabilitation: Transforming Traumatic Brain Injury Rehabilitation (PAIR TBI)
Chun Y. Seow, Department of Pathology and Laboratory Medicine
Mechanisms underlying the bronchodilatory effect of deep inspiration in health and asthma: from airway smooth muscle to the whole lung
Nika Shakiba, School of Biomedical Engineering
A bioengineering platform to promote safe cell therapies
*Conditionally funded at time of posting
Amanda K. Slaunwhite and Tonia L. Nicholls, School of Population and Public Health and Christian G. Schütz, Department of Psychiatry
An evaluation of the health, criminal justice, and service use outcomes of the Ministry of Health assuming responsibility for prison health care services in BC (PRISM-BC)
Patricia M. Spittal, School of Population and Public Health
The Cedar Project: Strengthening Our Spirit Intervention for Indigenous peoples who use drugs in two Canadian cities
John A. Staples, Department of Medicine
Drug overdose after departure from hospital against medical advice
Aline Talhouk, Michael S. Anglesio and Deborah M. Money, Department of Obstetrics and Gynecology and Anna Tinker, Department of Medicine
Digital self-tracking and self-testing for early detection of endometrial cancer
Michael Underhill, Department of Cellular and Physiological Sciences and School of Biomedical Engineering
Fate and function of mesenchymal progenitors within the medulloblastoma tumour microenvironment
Michael Underhill, Department of Cellular and Physiological Sciences and School of Biomedical Engineering
Mesenchymal progenitors in liver fibrosis – quiescence as a therapeutic target
Filip Van Petegem, Department of Biochemistry and Molecular Biology
Regulatory mechanisms of voltage-gated calcium channels
Filip Van Petegem, Department of Biochemistry & Molecular Biology
Structural and functional investigation of Junctophilins in health and disease
Paul Yong, Michael S. Anglesio, Ali Bedaiwy Mohamed, and Aline Talhouk, Department of Obstetrics and Gynecology
Clinical-biomarker predictors of outcome after endometriosis surgery
Priority announcement grants
Priority Announcement: Epigenetics/epigenomics in human health or disease
Donald Sin and Janice Leung, Department of Medicine
Blood Epigenetic Age Biomarkers and Health Outcomes in COPD
See the full list of recipients here.