A total of 54 projects led by UBC Faculty of Medicine researchers were awarded more than $26 million in combined funding through the Canadian Institutes of Health Research Project Grant: Fall 2022 competition.
The funding includes:
- 26 projects led by UBC Faculty of Medicine researchers awarded Project Grants totaling $23.8 million.
- Nine projects led by UBC Faculty of Medicine researchers awarded Bridge Grants totaling $900,000.
- 18 projects led by UBC Faculty of Medicine researchers awarded Priority Announcements totalling $1.9 million.
Across the university, 67 projects led by UBC researchers received more than $30 million in combined funding.
On a national level, CIHR announced a total of 382 research grants, plus 93 bridge grants, for a total investment of approximately $325 million. In addition, 190 priority announcement grants were funded for a total amount of $22 million and 12 supplemental prizes were awarded for a total of $375,000.
Faculty of Medicine-led Project Grants
- Deconvoluting Prognostic and Targetable Features of Endometrioid Ovarian Carcinomas of No Specific Molecular Profile
UBC Principal Investigator(s): Michael Anglesio (Obstetrics & Gynaecology); Aline Talhouk (Obstetrics & Gynaecology); Mark Carey (Obstetrics & Gynaecology)
Research Institution: University of British Columbia - A pilot clinical trial to evaluate the feasibility and acceptability of: A prospective, unblinded, randomized-controlled, multicenter biomarker intervention trial of a urinary CXCL10 clinical surveillance program in pediatric kidney transplant recipients for early ascertainment and treatment of subclinical allograft inflammation and preservation of kidney transplant function
UBC Principal Investigator(s): Tom Blydt-Hansen (Pediatrics)
Research Institution: BC Children’s Hospital Research Institute - Role of XIST in human X-chromosome inactivation and health
UBC Principal Investigator(s): Carolyn Brown (Medical Genetics)
Research Institution: University of British Columbia - Understanding epigenetic regulation and modulation of cell stress responses by the cholesterol transporter, scavenger receptor-B1 as a novel target for treating advanced prostate cancer
UBC Principal Investigator(s): Michael Cox (Urologic Sciences); Kishor Wasan (Urologic Sciences)
Research Institution: University of British Columbia - Neck Muscle and Head-Neck Dynamics in Rollover Crashes
UBC Principal Investigator(s): Peter Cripton (School of Biomedical Engineering)
Research Institution: University of British Columbia - Newly Optimized LNP Systems for Genetic drugs and Gene therapy in Neurological diseases
UBC Principal Investigator(s): Pieter Cullis (Biochemistry & Molecular Biology); Brian MacVicar (Psychiatry)
Research Institution: University of British Columbia - High-throughput characterization of transcription factor variants in yeast
UBC Principal Investigator(s): Carl De Boer (School of Biomedical Engineering)
Research Institution: University of British Columbia - Investigation of Neutrophil Extracellular Trap DNA ( NET-DNA) induced signaling in the progression of Pancreatic Ductal Adenocarcinoma
UBC Principal Investigator(s): Shoukat Dedhar (Biochemistry & Molecular Biology)
Research Institution: B.C. Cancer Research Centre (Vancouver) - Re-imagining Recovery with Young People Who Use(d) Drugs and Their Caregivers in Metro Vancouver: A Longitudinal Qualitative and Community-Based Participatory Study
UBC Principal Investigator(s): Danya Fast (Medicine)
Research Institution: University of British Columbia - Life Course Trajectories of Mental Health from the Early Years to Young Adulthood: An Ecological Systems and Intersectionality Perspective
UBC Principal Investigator(s): Anne Gadermann (School of Population & Public Health)
Research Institution: University of British Columbia - Physiological and morphological mechanisms of increased dyspnea in females with COPD
UBC Principal Investigator(s): Jordan Guenette (Physical Therapy)
Research Institution: University of British Columbia - Neuropathology of cognitive impairment in chronic schizophrenia
UBC Principal Investigator(s): Veronica Hirsch Reinshagen (Pathology & Laboratory Medicine)
Research Institution: University of British Columbia - Evaluating the utility of long-read genome sequencing for uncovering causal genetic variation and epigenetic signatures of rare disease
UBC Principal Investigator(s): Steven Jones (Medical Genetics)
Research Institution: Genome Sciences Centre - Localized immuno-cloaking organ engineering approach to prevent transplant rejection without immunosuppressants
UBC Principal Investigator(s): Jayachandran Kizhakkedathu (Pathology & Laboratory Medicine, Michael Smith Laboratories)
Research Institution: University of British Columbia - ACTIVE: Adding Life to Years in Cognitive Frailty by Preventing Falls
UBC Principal Investigator(s): Teresa Liu-Ambrose (Physical Therapy); Linda Li (Physical Therapy); Kenneth Madden (Medicine)
Research Institution: University of British Columbia - Innate immune mechanisms of viral myocarditis: Role of the cytosolic DNA-sensing pathway
UBC Principal Investigator(s): Honglin Luo (Pathology & Laboratory Medicine)
Research Institution: University of British Columbia - Development and functional diversity of innate lymphoid cells
UBC Principal Investigator(s): Kelly McNagny (Medical Genetics, School of Biomedical Engineering)
Research Institution: University of British Columbia - Trajectories of STBBIs, access to health services and psychosocial determinants among gay, bisexual and other men who have sex with men in three Canadian cities
UBC Principal Investigator(s): David Moore (Medicine)
Research Institution: University of British Columbia - Comparing observation vs. bracing in radiologically dysplastic, stable hips in infants with developmental dysplasia of the hip. An International Multi-Centre Non-Inferiority Randomized Control Trial
UBC Principal Investigator(s): Kishore Mulpuri (Orthopaedics)
Research Institution: B.C. Children’s Hospital (Vancouver) - Deciphering the Hottest Immune Neighbourhoods in Ovarian Cancer to Advance Immunotherapy
UBC Principal Investigator(s): Brad Nelson (Medical Genetics)
Research Institution: BC Cancer, part of PHSA (Victoria)
*conditional award at time of posting - Parent-of-Origin-Aware Genomic Analysis in Hereditary Cancer
UBC Principal Investigator(s): Kasmintan Schrader (Medical Genetics); Peter Lansdorp (Medical Genetics); Steven Jones (Medical Genetics)
Research Institution: University of British Columbia - The impact of chromosomal instability on ovarian cancer progression
UBC Principal Investigator(s): Adi Steif (Medical Genetics)
Research Institution: BC Cancer, part of PHSA (Vancouver) - Dominant genetics of cohesin pathway proteins to kill cancer
UBC Principal Investigator(s): Peter Stirling (Medical Genetics)
Research Institution: BC Cancer, part of PHSA (Vancouver) - Genetic mapping of a stress response and pro-longevity network in C. elegans and human cancer cells
- Using translational biomarkers to define whether plane of motion and complexity of head kinematics modifies biomarker and neuropathological responses to concussion in mice and humans
UBC Principal Investigator(s): Cheryl Wellington (Pathology & Laboratory Medicine); Peter Cripton (School of Biomedical Engineering); Piotr Kozlowski (Radiology, Urologic Sciences)
Research Institution: University of British Columbia - Smart Discharges in children over 5: Expanding a personalized public health approach to improving discharge care in resource-limited settings
UBC Principal Investigator(s): Matthew Wiens (Anesthesiology, Pharmacology & Therapeutics)
Research Institution: University of British Columbia
UBC Principal Investigator(s): Stefan Taubert (Medical Genetics)
Research Institution: University of British Columbia
Faculty of Medicine-Led Bridge Grants
- Decoding the impact of single cell mutational processes in triple negative breast cancer and high grade serous ovarian cancer
UBC Principal Investigator(s): Samuel Aparicio (Pathology & Laboratory Medicine)
Research Institution: BC Cancer, part of PHSA (Vancouver) - International Study to Field-Test a New Patient-Reported Outcome Measure for Children with Lower Limb Differences
UBC Principal Investigator(s): Anthony Cooper (Orthopaedics)
Research Institution: University of British Columbia - A novel oncolytic virotherapy to overcome drug-resistance in acute myeloid leukemia
UBC Principal Investigator(s): Xiaoyan Jiang (Medical Genetics)
Research Institution: BC Cancer, part of PHSA (Vancouver) - Targeting sodium channels for beta-cell protection and insulin secretion in diabetes
UBC Principal Investigator(s): James Johnson (Cellular & Physiological Sciences, Surgery)
Research Institution: University of British Columbia
*conditional award at time of posting - Advanced Multi-parametric Retinal Imaging for AMD Classification Modeling
UBC Principal Investigator(s): MyeongJin Ju (School of Biomedical Engineering, Ophthalmology & Visual Sciences); Eduardo Navajas (Ophthalmology & Visual Sciences)
Research Institution: University of British Columbia - Investigating altered sensorimotor processing in Huntington disease
UBC Principal Investigator(s): Lynn Raymond (Psychiatry)
Research Institution: University of British Columbia - Development and evaluation of novel nanoparticle formulations for therapeutic genome editing
UBC Principal Investigator(s): Anna Blakney (School of Biomedical Engineering, Michael Smith Laboratories)
Research Institution: University of British Columbia - Examining drivers of disparities in experiences and outcomes of perinatal care in Canada through community participatory action research
UBC Principal Investigator(s): Saraswathi Vedam (Family Practice)
Research Institution: University of British Columbia - Genetic and acquired defects in prohormone processing in diabetes
UBC Principal Investigator(s): Bruce Verchere (Surgery, Pathology & Laboratory Medicine)
Research Institution: University of British Columbia
*conditional award at time of posting
Faculty of Medicine-led Priority Announcements
- People with Prediabetes and Mild Diabetes: characteristics, management and outcomes
UBC Principal Investigator(s): Anshula Ambasta (Anesthesiology, Pharmacology & Therapeutics); Wade Thompson (Anesthesiology, Pharmacology & Therapeutics); Colin Dormuth (Anesthesiology, Pharmacology & Therapeutics)
Research Institution: University of British Columbia
Project Grant – PA: Patient-Oriented Research: Early-Career Investigator - Cancer-driver events in normal endometrium: impact on healthy aging and reproduction
UBC Principal Investigator(s): Michael Anglesio (Obstetrics & Gynaecology); Mohamed Ali Bedaiwy (Obstetrics & Gynaecology); Paul Yong (Obstetrics & Gynaecology); Gillian Hanley (Obstetrics & Gynaecology);
Research Institution: University of British Columbia
Project Grant – PA: Women’s Health Research – Early Career Researcher Grant - Optimization of next-generation RNA vaccines for pandemic preparedness
UBC Principal Investigator(s): Anna Blakney (Michael Smith Laboratories, School of Biomedical Engineering)
Research Institution: University of British Columbia
Project Grant – PA: Pandemic Preparedness and Health Emergencies Research - Identifying altered gene regulatory network states and underlying mechanisms in atrial fibrillation, a model polygenic disease
UBC Principal Investigator(s): Carl De Boer (School of Biomedical Engineering)
Research Institution: University of British Columbia
Operating Grant – PA: Genetics (Bridge Funding: Research Priorities) - Endometriosis and ovarian cancer: Understanding which patients are at high risk for ovarian cancer
UBC Principal Investigator(s): Gillian Hanley (Medicine, Obstetrics & Gynaecology); Anglesio, Michael S (Obstetrics & Gynaecology)
Research Institution: University of British Columbia
Project Grant – Priority Announcement: Early Detection/Cancer Prevention - SNF2 Histone Linker PHD RING Helicase as a novel tumor suppressor gene and risk factor in lung adenocarcinoma development
UBC Principal Investigator(s): William Lockwood (Pathology & Laboratory Medicine)
Research Institution: B.C. Cancer Research Centre (Vancouver)
Project Grant – Priority Announcement: Cancer Research - Systematic characterization of membrane contact sites in budding yeast
UBC Principal Investigator(s): Christopher Loewen (Cellular & Physiological Sciences)
Research Institution: University of British Columbia
Operating Grant – PA: Genetics (Bridge Funding: Research Priorities)
*conditional award at time of posting - Elucidating the mitotic mechanisms that are needed for alveologenesis in the pregnant mammary gland and are likely to be disturbed in pregnancy-associated breast cancer.
UBC Principal Investigator(s): Christopher Maxwell (Pediatrics)
Research Institution: University of British Columbia
Project Grant – PA: Breast Cancer Research
*conditional award at time of posting - Podocalyxin’s role in tumor invasion, metastasis, and immune evasion
UBC Principal Investigator(s): Kelly McNagny (Medical Genetics, School of Biomedical Engineering); Calvin Roskelley (School of Biomedical Engineering, Cellular & Physiological Sciences)
Research Institution: University of British Columbia
Project Grant – PA: Breast Cancer Research - Artificial intelligence assisted Method, Optimizing the Prediction of Patient Outcomes among Long COVID-19 Patients
UBC Principal Investigator(s): Savvakis Nicolaou (Radiology)
Research Institution: University of British Columbia
Project Grant – PA: Pandemic Preparedness and Health Emergencies Research - Translating Epigenomics into Clinical Care for Synovial Sarcoma
UBC Principal Investigator(s): Torsten Nielsen (Pathology & Laboratory Medicine)
Research Institution: University of British Columbia
Project Grant – Priority Announcement: Pediatric Cancer Research - A synthetic biology approach to unlocking the role of the ribosome in cell competition
UBC Principal Investigator(s): Nika Shakiba (School of Biomedical Engineering)
Research Institution: University of British Columbia
Operating Grant – PA: Genetics (Bridge Funding: Research Priorities) - Exploring the potential of type-1 regulatory T cells in treatment and recovery from intestinal inflammation in inflammatory bowel disease
UBC Principal Investigator(s): Theodore Steiner (Medicine)
Research Institution: BC Children’s Hospital Research Institute
Project Grant – Priority Announcement: Infection and Immunity - Improving endometrial cancer risk prediction by including genetic, environmental, and temporal exposures
UBC Principal Investigator(s): Aline Talhouk (Obstetrics & Gynaecology)
Research Institution: University of British Columbia
Project Grant – PA: Women’s Health Research – Early Career Researcher Grant - Harnessing early life developmental trajectories and the gut microbiota to identify new ways to prevent asthma and obesity
UBC Principal Investigator(s): Stuart Turvey (Pediatrics)
Research Institution: University of British Columbia
Operating Grant – PA: Genetics (Bridge Funding: Research Priorities) - A master transcription factor driving cell lineage reprogramming in neuroendocrine prostate cancer development and progression
UBC Principal Investigator(s): Yuzhuo Wang (Urologic Sciences)
Research Institution: BC Cancer, part of PHSA (Vancouver)
Project Grant – Priority Announcement: Cancer Research - Deep Learning-Based Design of Synthetic Promoters for Oligodendroglia-Specific Expression
UBC Principal Investigator(s): Wyeth Wasserman (Medical Genetics)
Research Institution: BC Children’s Hospital Research Institute
Operating Grant – PA: Genetics (Bridge Funding: Research Priorities)
*conditional award at time of posting - Care, Health, Economics, and Society: Spillover Effects of Caregiving in Canada
UBC Principal Investigator(s): Wei Zhang (School of Population & Public Health); Amy Salmon (School of Population & Public Health)
Research Institution: Centre for Health Evaluation & Outcome Sciences (Vancouver, BC)
Project Grant – PA: Patient-Oriented Research: Early-Career Investigator