Jibin Sadasivan

Ever since I was first introduced to the fascinating field of biology, I have been intrigued by the basic molecular mechanism driving biological processes like gene expression. When I realized that I could pursue this as my career, there was no looking back. I got to explore different aspects of scientific research early during my undergrad degree at the Indian Institute of Science Education and Research in Kolkata. The coronavirus projects I undertook in Prof. Jayasri Das Sarma’s lab during my master’s program solidified my interest in virology. I enjoy the process of discussing, designing, performing and presenting experiments. I wanted to further develop my analytical and experimental skills to further my independent research. The trust and support from my mentors, teachers, family and friends facilitated my journey and ultimate decision to pursue a PhD. It is with this enthusiasm I started my PhD in molecular virology at UBC.

I study viruses, which are tiny particles that invade and infect host cells. A virus inserts its genetic material into a host cell and takes over the host’s machinery in order to replicate itself. The goal of my research is to investigate how viral proteins interact with and trick host cells to cause infection. I am currently investigating how coronavirus encoded proteases (a protein that can cleave other proteins) are remodelling the host environment for the virus to replicate and evade host immune responses. This work will provide insights into the fundamental virus-host interactions and contribute to our understanding of the coronavirus life cycle.

I am very excited and curious about where my research will lead to in the days ahead, especially since I am pursuing research on the coronavirus and working directly towards discovering novel therapeutic targets for this virus. I am also hoping to see the progress in coronavirus vaccine research, so that myself and others can travel to meet our near and dear ones.

I am fortunate to be able to work directly towards understanding the coronavirus during this crucial time. Being able to contribute directly towards overcoming this pandemic has been very satisfying and has kept me going emotionally. During lockdown, I have had a little more time for myself and, with great pleasure, have found myself spending more time talking with my friends and family. I make sure to connect with them often.

Biking with my friends around the neighbourhood.