The University of British Columbia
UBC - A Place of Mind
The University of British Columbia
Faculty of Medicine
  • Home
  • Admissions
  • About
    • Strategic Plan
    • Vision & Values
    • Land Acknowledgement
    • Indigenous Health
    • Leadership
    • Academic & Research Units
    • Campuses
    • Facts & Figures
    • Careers
    • Contact
  • News
    • Feature Stories
    • Pathways Magazine
    • The Next Big Question
  • Education
    • Programs
    • Faculty Development
    • Health Education Scholarship
    • Continuing Professional Development
  • Research
    • Priority Areas
    • Canada’s Immuno-Engineering and Biomanufacturing Hub
    • COVID-19 Clinical Research Coordination Initiative
    • Academy of Translational Medicine
    • Edwin S.H. Leong Centre for Healthy Aging
    • Centres & Institutes
    • National Prizes
  • Giving
    • Impact of Giving
    • By the Numbers
    • Ways to Give
    • Webinar Series
    • Contact Us
  • Prospective Students
  • Current Learners
    • Policies & Procedures
    • Respectful Environments, Equity, Diversity & Inclusion
    • Mistreatment Help
    • MD & Undergrad Research
    • Summer Student Research Program
    • Multidisciplinary Research Program in Medicine
    • Grad & Postdoc Education
  • Faculty & Staff
  • Clinical Faculty
    • Becoming Clinical Faculty
    • Appointment Policy & Compensation Terms
    • Teaching Tracking & Payment System
    • Services & Perks
    • Career Development
    • Awards
    • Celebrating Clinical Faculty
    • Advisory Council
    • Contacts
  • Alumni
» Home » News » Scientists catch brain damage in the act

Contact

Communications
UBC Faculty of Medicine
Email: communications.med@ubc.ca
Office: 604.822.2421

Scientists catch brain damage in the act

By Patricia Angel | March 13, 2014

Brian MacVicar, Professor in the Department of Psychiatry

Brian MacVicar, Professor in the Department of Psychiatry

Scientists have uncovered how inflammation and lack of oxygen conspire to cause brain damage in conditions such as stroke and Alzheimer’s disease.

The discovery, published today in Neuron, brings researchers a step closer to finding potential targets to treat neurodegenerative disorders.

Chronic inflammation and hypoxia, or oxygen deficiency, are hallmarks of several brain diseases, but little was known about how they contribute to symptoms such as memory loss.

The study used state-of-the-art techniques that reveal the movements of microglia, the brain’s resident immune cells. Brain researcher Brian MacVicar had previously captured how they moved to areas of injury to repair brain damage.

The new study shows that the combination of inflammation and hypoxia activates microglia in a way that persistently weakens the connection between neurons. The phenomenon, known as long-term depression, has been shown to contribute to cognitive impairment in Alzheimer’s disease.

“This is a never-before-seen mechanism among three key players in the brain that interact together in neurodegenerative disorders,” says MacVicar with the Djavad Mowafaghian Centre for Brain Health at UBC and Vancouver Coastal Health Research Institute.

“Now we can use this knowledge to start identifying new potential targets for therapy.”

Contact Information

Communications
UBC Faculty of Medicine
Email: communications.med@ubc.ca
Office: 604.822.2421
Faculty of Medicine
317 - 2194 Health Sciences Mall
Vancouver, BC Canada V6T 1Z3
Tel 604 822 2421
Website www.med.ubc.ca
Find us on
    
Back to top
The University of British Columbia
  • Emergency Procedures |
  • Terms of Use |
  • Copyright |
  • Accessibility