The Canadian Institutes for Health Research (CIHR) has announced its latest CIHR project grants and 40 projects led by researchers at the UBC Faculty of Medicine were awarded more than $27 million in grants.
Funding for full project grants was awarded to a total of 50 projects led by UBC researchers and its affiliated health authority research centres. An additional eight projects at UBC were funded through priority announcement grants and bridge grants.
As CIHR’s largest funding program, the project grant competitions support multi-year grants for researchers at various stages in their careers as they conduct research projects that cover the full range of health research topics.
The UBC Faculty of Medicine recipients and their project titles are:
Laura Arbour and Leigh Anne Swayne
When Rare Becomes Common: The impact of the AnkB p.S646F variant on heart disease in a Northern BC First Nation – $1,384,650
Sean Barbour
Development of a personalized medicine approach to corticosteroid treatment in IgA nephropathy – $292,976
Ryan Brinkman and Andrew Weng
Machine Learning for Flow Cytometry Clinical Data and Trial Analysis – $317,475
Liam Brunham and John Boyd
CETP Inhibition as a novel treatment to remove pathogen lipids and improve survival in sepsis – $612,000
James Christenson and Kendall Ho
Kwiis hen niip – Change: Change for emergency care services in rural and remote Indigenous communities in British Columbia. – $1,172,436
Kathleen Deering
Longitudinal impacts of violence and stigma on HIV care continuum and broader health care access among WLWH: the SHAWNA Project – $956,250
Caigan Du and Jayachandran Kizhakkedathu
Novel hyperbranched polyglycerol-derived biliary excretable osmotic agents for peritoneal dialysis – preclinical evaluation – $474,300
Franck Duong
Development of a peptide-based membrane mimetic for solution studies in membrane protein research. – $864,450
Jan Friedman and Inanc Birol
Long-read sequencing and bioinformatics analysis to identify cryptic genetic mutations in patients with undiagnosed intellectual disability – $1,063,351
William Gibson
Functional Studies of Coding Variants in Polycomb Repressive Complex Found in Humans – $612,000
Gillian Hanley and Timothy Oberlander
A population-level linked data study of the long-term developmental impacts of prenatal antidepressant exposure – $359,552
Sarah Henderson
The Effects of In Utero and Neonatal Wildfire Smoke Exposure on Birth Outcomes and Health in Early Life – $325,124
William Honer and William Panenka
Neuropsychiatric complications of co-morbid illness in people living in homelessness or precarious housing – $1,235,475
Xiaoyan Jiang
Targeting a novel miR-185/PAK6 axis to overcome drug-resistance in human leukemia – $902,700
James Johnson
Mechanisms by which hyperinsulinemia promotes pancreatic cancer – $1,090,125
James Johnson
Mechanisms linking reduced circulating insulin to insulin sensitivity and longevity – $1,090,125
Philipp Lange
Tumour microenvironment mediated cell surface shedding creates unique targets and markers – $977,425 (includes $25,000 Priority Announcement Prize: Early Career Investigator in Cancer)
Teresa Liu-Ambrose and Liisa Galea
Sex Matters: Understanding Sex Differences in Exercise Efficacy on Brain Health in Mild Cognitive Impairment – $661,724
William Lockwood
The effects of smoking marijuana on lung cancer development: implications for screening and early detection. – $688,500
Christopher A Maxwell
Mechanisms that impact the cell division axis and phenotype for BRCA1-mutant mammary epithelial cells. – $837,675
Heather Mckay and Joan Sims-Gould
How can health benefits of an effective, scaled-up, health promotion model for older adults be sustained? – $883,576
Brad Nelson
Mechanisms of B cell-mediated immunity in human cancer – $1,193,400
Wendy Norman, Kimberlyn McGrail and Bonnie Henry
The CART Mife-Outcomes study: Relating Canada’s unique mifepristone regulations to health system events, costs and access to abortion, using linked health administrative data. – $524,024
Robert Olson and Scott Tyldesley
A phase III randomized controlled trial and economic evaluation of Stereotactic Ablative Radiotherapy (SABR) for Comprehensive treatment of OligoMETastatic (1-3 metastases) cancer: SABR-COMET-3 – $699,380
Josef Penninger
Investigating the role of the BH4 pathway in Parkinson’s Disease (PD) – $868,275
Matthew Ramer
Hypoxia mimicry for enhancing peripheral nerve regeneration – $807,075
Wendy Robinson
Genetics and epigenetics of sex differences in placental and fetal development – $604,350
Kate Shannon
Towards Equitable Sexual Health Care in BC: Centring the Voices of Cis and Trans Feminine Youth and Young Women in Policy and Practice – $960,075
Noah Silverberg
Mobilizing early management of mental health complications after mild traumatic brain injury (M4) – $749,700
Aline Talhouk and Jessica McAlpine
Pre-operative Risk Stratification in Endometrial Cancer to Inform Surgical Management – $263,925
Guy Tanentzapf
The regulation of Cell-Matrix Adhesion in mouse development and tissue homeostasis – $921,825
Decheng Yang
Role of transcription factor NFAT5 in viral myocarditis: a novel strategy for therapy – $604,350
Calvin Yip
Investigating the structure and function of the human autophagy regulator EPG5 – $856,800
Amina Zoubeidi
The role of the lineage oncogene ASCL1 in treatment-induced neuroendocrine prostate cancer – $841,500
Priority Announcement Grants
Jan Dutz
Phototherapy to modulate regulatory T cells and prevent autoimmune disease
(Priority Announcement: Nutrition, Metabolism and Diabetes) – $100,000
Nichole Fairbrother
Perinatal Anxiety Disorder Screening Study
(Priority Announcement: Neurosciences, Mental Health and Addiction) – $100,000
Troy Grennan
Predicting and Evaluating Anal Cancer in HIV with novel biomarkers: The PEACH Study
(Priority Announcement: HIV/AIDS) – $100,000
Ging-Yuek Hsiung and Ian Mackenzie
Diagnostic and predictive biomarkers for Frontotemporal Dementia with TDP-43 pathology
(Priority Announcement: Neurosciences, Mental Health and Addiction) – $100,000
Andrea Krüsi
Criminalization, Public Health and Incarceration – A participatory qualitative and digital storytelling investigation of the experiences of cis and trans women living with HIV
(Priority Announcement: Patient-Oriented Research: Early-Career Investigator) – $100,000
Cheryl Wellington
Using bioengineered human vessels to understand how brain and peripheral apoE affect cerebrovascular functions relevant to Alzheimer’s Disease
(Priority Announcement: Neurosciences, Mental Health and Addiction) – $100,000